From vampire facelifts to bird poop facials, in the aesthetics universe, nothing seems too bizarre in the quest for complexion perfection. The latest treatment to make headlines and social feeds is polynucleotides. Derived from – wait for it – salmon or trout sperm, this injectable treatment promises to jumpstart skin regeneration.
But are there serious therapeutic benefits of polynucleotides? Or is this another wacky beauty fad that’s one fish too far? Let’s swim upstream and find out.
So, what are polynucleotides?
Don’t worry, it’s not literal salmon sperm that’s injected. Polynucleotides are filtered, purified and sterilised natural DNA fractions derived from the sperm. Classed as a ‘biostimulator’, rather than artificially plump skin like a traditional dermal filler would, polynucleotides work as a nourishing medicine for skin cells.
Once inside, the natural DNA fractions mirror human DNA and get to work on boosting collagen and elastin, upping hydration and thickening the epidermis naturally thanks to stimulating your body’s fibroblast production. Furthermore, polynucleotides are antioxidants with anti-inflammatory properties to lower skin inflammation.
Polynucleotides aren’t even a new discovery. Before entering the aesthetics arena, they had a long medical track record of successfully treating issues like knee osteoarthritis and chronic wounds.
What can polynucleotides treat?
Aesthetically, polynucleotides are used around the eye area, whole face, neck or décolleté to improve the appearance of aging skin.
Plumping fine lines and wrinkles aside, since polynucleotides are regenerative and anti-inflammatory, the injectable can also be used to treat skin conditions like scarring, acne, rosacea, stretch marks and hyperpigmentation.

What are the benefits of polynucleotides?

The good news is that science backs up the efficacy of polynucleotides as an aesthetic treatment. One 2021 Italian study revealed that over 80% of participants reported an improvement on their face, periocular area, décolleté and neck, hands, scalp, and stretch marks. It concluded by saying, “The expert consensus illustrates the value of intradermal PH HPT™ as biostimulatory boosters for priming and revitalization of face and body skin thanks to their efficacy on dermal cells.”
If firmer skin, diminished eye bags, smoother texture and even skin tone with reduced pigmentation marks are something you’re seeking, polynucleotides could be for you.
Also, if you’re averse to the idea of dermal fillers or Botox, polynucleotides are a more natural skincare solution that works at a therapeutic level, rather than by volumising your skin artificially.

Do polynucleotides treatments carry any risks?

Very few. The aforementioned Italian study stated that PN‐HPT™‐based medical devices are a safe and effective aesthetic treatment strategy for skin rejuvenation, revitalization, and toning of the skin on the face or body.

Polynucleotides in the UK

Unlike Botox®, polynucleotide administration does not require a prescription. This means that the Industry is essentially unregulated. If you are considering having polynucleotides it is recommended that you check that your practitioner is registered with a professional body. Although polynucleotides are classed as a medical device and do not require a prescription, it is recommended that you choose a prescribing practitioner because if something does go wrong, you may need a prescription to correct this.

Important note re polynucleotides

An experienced injector and prescriber will always ensure that a thorough consultation is performed and should be happy to answer any questions you may have. Consider asking the following;

What is your level of experience and qualifications?
What is the name or brand of product/device you are using?
Are there any risks or side effects I could experience?
What will happen if anything goes wrong?
What insurance cover do you have for polynucleotide treatments?


1 polynucleotide treatment £280
When bought as a course of 2 treatments (3 weeks apart) £500
When bought as a course of 3 treatments (3 weeks apart) £700